<br><div><aside class="gnt_em gnt_em__fp gnt_em_vp__tp gnt_em__el" aria-label="Video - NFL Week 3 picks and predictions | Lorenzo's Locks"/><p class="gnt_ar_b_p">The <a target="_blank" href="https://www.usatoday.com/sports/nfl/san-francisco-49ers/" rel="noopener" data-t-l=":b|e|k|${u}" class="gnt_ar_b_a">San Francisco 49ers</a> are no strangers to success, but the storied franchise has a chance to get off to a better start than it has in recent years.</p><p class="gnt_ar_b_p">With a win <a target="_blank" href="http://www.usatoday.com/story/sports/nfl/2023/08/29/2023-nfl-thursday-night-game-regular-season-info/70644187007/" rel="noopener" data-t-l=":b|e|k|${u}" class="gnt_ar_b_a">Thursday night</a> against the <a target="_blank" href="https://www.usatoday.com/sports/nfl/new-york-giants/" rel="noopener" data-t-l=":b|e|k|${u}" class="gnt_ar_b_a">New York Giants</a>, the 49ers will have just their second 3-0 opening in 25 years, with the other such start coming in 2019. Stopping the San Francisco could prove to be a tall task for New York, which <a target="_blank" href="http://www.usatoday.com/story/sports/nfl/2023/09/18/nfl-injury-tracker-week-3/70892956007/" rel="noopener" data-t-l=":b|e|k|${u}" class="gnt_ar_b_a">will be without Saquon Barkley</a> as the running back recovers from an ankle ailment. The Giants, however, <a target="_blank" href="http://www.usatoday.com/story/sports/nfl/giants/2023/09/17/ny-giants-vs-arizona-cardinals-live-updates-analysis-daniel-jones-saquon-barkley-andrew-thomas/70861939007/" rel="noopener" data-t-l=":b|e|k|${u}" class="gnt_ar_b_a">rallied from a 21-point deficit</a> last Sunday to defeat the <a target="_blank" href="https://www.usatoday.com/sports/nfl/arizona-cardinals/" rel="noopener" data-t-l=":b|e|k|${u}" class="gnt_ar_b_a">Arizona Cardinals</a> for their first win of the season.</p><p class="gnt_ar_b_p">USA TODAY Sports will have a live breakdown of the game, so check back for more information on all the action:</p><aside aria-label="advertisement" class="gnt_m gnt_x gnt_x__lbl gnt_x__al"/><h2 class="gnt_ar_b_mt"><a target="_blank" id="gpd-1695337309011" class="gnt_ar_b_ba" rel="noopener"> What time is kickoff for Giants vs. 49ers on 'Thursday Night Football'?</h2><p class="gnt_ar_b_p">The Giants and 49ers will kick off at 8:15 p.m. ET on Sept. 21.</p><p class="gnt_ar_b_p"><strong>NFL STATS CENTRAL:</strong> <a target="_blank" rel="noopener" data-t-l=":body nav (scores)|e|auto spike click:6|${u}" class="gnt_ar_b_a" href="https://sportsdata.usatoday.com/football/nfl/scores">The latest NFL scores, schedules, odds, stats and more.</a></p><h2 class="gnt_ar_b_mt"><a target="_blank" id="gpd-1695337311271" class="gnt_ar_b_ba" rel="noopener"> How can I watch Giants vs 49ers on 'Thursday Night Football'?</h2><p class="gnt_ar_b_p">Giants vs. 49ers will be <a target="_blank" href="https://amzn.to/3EKBqgh" rel="noopener" data-t-l=":b|e|k|${u}" class="gnt_ar_b_a">streaming on Amazon Prime Video</a> and will be broadcast in local markets only. The game is also available to <a target="_blank" href="https://www.fubo.tv/welcome?irad=343747&irmp=1205322&subId1=USAT&subId2=2023-24%20NFL%20Season&subId3=Casey" rel="noopener" data-t-l=":b|e|k|${u}" class="gnt_ar_b_a">stream for free on Fubo</a>.</p><aside aria-label="advertisement" class="gnt_m gnt_x gnt_x__lbl gnt_x__al"/><h2 class="gnt_ar_b_mt"><a target="_blank" id="gpd-1695337395932" class="gnt_ar_b_ba" rel="noopener"> Giants, 49ers inactives for Thursday night: Brandon Aiyuk out</h2><p class="gnt_ar_b_p">The 49ers will be without starting wide receiver Brandon Aiyuk due to a shoulder injury that he suffered Week 2 versus the Los Angeles Rams. The 49ers also announced that QB Brandon Allen, OL Nick Zakelj, RB Tyrion Davis-Price, LB Jalen Graham, DL Kalia Davis and CB Ambry Thomas are...</p></div> <style> .wrapper { text-align: center; } </style> <div class="wrapper"> <a class="button" href ="https://www.usatoday.com/story/sports/nfl/2023/09/21/giants-niners-thursday-night-football-updates-highlights/70924326007/">Read more <span>➤</span></a> </div>
